|Name||Mr. Aaron Garrison|
|Organization||University of Florida|
Discovery and Development of Halogenated Phenazines as Biofilm Eradicators and Anti-tuberculosis Agents
Aaron T. Garrison, Yasmeen Abouelhassan, Dimitris Kallifidas, Hendrik Luesch, Robert W. Huigens III
University of Florida
Biofilms are a collection of microbial communities enclosed within matrices of extracellular polymeric substances. The bacterial biofilms that arise from established infections are endowed with heightened levels of antibiotic tolerance, rendering current treatment options less effective. Bacterial infections (80% of which are biofilm-related) lead to the deaths of more than 500,000 people annually in the U.S. alone. There are currently no clinically-available agents which eradicate biofilm-associated infections; that is, agents which kill biofilm-encased persister cells via growth-independent mechanisms. Our group recently identified a series of halogenated phenazine (HP) analogues capable of eradicating bacterial biofilms (S. aureus, S. epidermidis, E. faecium) while demonstrating minimal mammalian cytotoxicity and hemolytic activities. However, the synthetic methods by which we generate HPs present some limitations. Improved HP syntheses could allow for faster identification and development of future HP biofilm eradicators.