In by admin

Name Ms. Anne-Claire Limon
Organization Chemistry Department - Dr. Bill Baker's Group
Type Poster
Topic Natural Products
Title

Isolation of NEW Alcyopterosin compounds produced by an Antarctic coral of the Sinularia sp.

Author(s)

Anne-Claire D. Limon and Bill J. Baker

Author Location(s)

Tampa, Florida

Abstract

Drug resistance causing the spread of infectious agents and diseases is a global problem, in need of innovative solutions and novel drugs. Marine organisms from Antarctica have been investigated for their potential natural product chemistry. Antarctic corals produce unique secondary metabolites as a defense mechanism to compensate for their immobility. These adaptations persist throughout evolution, accumulating novel secondary metabolites in subsequent generations. The compounds behind these chemical defense systems could be a significant source of novel chemistry to be further developed into new drugs.
The extraction and purification of extracts from an Antarctic coral, Sinularia sp. has led to the isolation of several known compounds of the alcyopterosin family alongside new chemistry showing evolution of pre-existing molecules over the years. Coral samples collected from Antarctica were freeze-dried, treated to Soxhlet extraction and liquid-liquid partition; then Medium Pressure Liquid Chromatography (MPLC) and High Pressure Liquid Chromatography (HPLC) were performed to purify terpenoid compounds. The purification process was guided by Nuclear Magnetic Resonance spectroscopy (NMR). Once characterized, isolates were subjected to assays against various infectious agents in order to assess bioactivity and drug potential.