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Name Mr. Sourabh Mishra
Organization University of Florida
Type Poster
Topic Organic Chemistry
Title

Facile Tuning of Atropisomeric P,N-Ligands Towards Efficient Enantioselective Catalysis

Author(s)

Sourabh Mishra, Ji Liu, Aaron Aponick

Author Location(s)

Center for Heterocyclic Compounds, Department of Chemistry, University of Florida

Abstract

Catalytic asymmetric conjugate addition reactions are very important tools for the assembly of chiral compounds and Meldrum’s acid derivatives are excellent acceptors for such transformations. Facile diversification of β–alkynyl adducts makes them highly useful targets and a new synthetic method using StackPhos, an imidazole–based atropisomeric P,N–ligand has been developed. Employing a ligand modification strategy, this transformation was achieved with a broad substrate scope and excellent enantioselectivity. Recent results using modified ligands will be presented, as well as the application of the method.