| Name | Mr. Anthony G Giacalone |
|---|---|
| Organization | USF |
| Type | Poster |
| Topic | Inorganic Chemistry |
| Title | ENCAPSULATION OF PHOTOACTIVE RU(II)(2,2’-BIPYRIDINE)2(BIO-ACTIVE MOLECULES)2 INTO A ZN-BASED POLYHEDRAL METAL ORGANIC FRAMEWORK AND ATTEMPTED ENCAPSULATION IN VARIOUS FE-BASED MIL SERIES METAL ORGANIC FRAMEWORKS |
| Author(s) | Anthony Giacalone1, Dr. Lukasz Wojtas2 and Dr. Randy W. Larsen3 |
| Author Location(s) | Department of Chemistry, University of South Florida, Tampa Fl, 33620 |
| Abstract |
Metal Organic Frameworks (MOFs) are a class of porous materials composed of organic ligands linked through metal clusters (molecular building blocks or MBBs) that have exceptional potential to serve as platforms for a wide array of applications including novel drug delivery. Drug delivery applications for MOFs are of increasing interest as these materials can contain a high weight percent of biologically active compounds within the large interior cavities while the relatively small pore sizes enables effective time release. Here we describe the development of a novel photodynamic therapy application of MOFs in which a Ru(II)(2,2’-bipyridine)2(BAM)2 (BAM = Bio-Active Molecule) cluster is encapsulated within the cavities of the Zn-based polyhedral MOF, USF2. Exposure of the new materials to white light results in the photo ejection of the BAM and subsequent egress to the bulk solvent through the exterior pores. Along with the encapsulation, and photo release of the Ru(II)(2,2’-bipyridine)2(BAM)2cluster within various water stable MOF’s is being explored starting with the Fe-based MIL series MOF’s. |
American Chemical Society - Florida Section
