|Name||Mr. Peter Vertesaljai|
|Organization||University of Florida|
TOWARDS TERPENOID SCAFFOLDS VIA MULTI-FUNCTIONALIZATION OF KNOEVENAGEL ADDUCTS
Peter Vertesaljai, Matthew Williams, and Alexander J. Grenning
Department of Chemistry, University of Florida, Gainesville FL 32611-7200, USA
Knoevenagel adducts obtained from inexpensive ketones and malonic acid derivatives readily undergo selective transformations under mild conditions which makes them attractive building blocks. Our research focuses on the utility of Knoevenagel adducts in scalable, divergent syntheses towards terpenoid natural products and their analogs. A sequence of alkylation/[3,3]-sigmatropic rearrangement/α-alkylation/ring-closing metathesis was devised to construct a library of angular polycyclic carbon frameworks. Diversity is introduced by proper choice of starting materials as well as late stage functional group interconversion.